منابع مشابه
Neuroprotective Effect of Celastrus Paniculatus Seed Extract in Epilepsy and Epilepsy-Associated Cognitive Deficits
Purpose: Cognitive deficit is one of the common comorbidity accompanying epilepsy. The present study evaluated the effect of Celastrus paniculatus (C- paniculatus) seed extract on seizure severity and cognitive deficit following Pentylenetetrazole (PTZ) -induced chemical kindling model. Methods: PTZ kindling model was developed by daily administration of sub-convulsive dose of PTZ 30 mg/kg for...
متن کاملEpilepsy, cognitive deficits and neuroanatomy in males with ZDHHC9 mutations
OBJECTIVE Systematic investigation of individuals with intellectual disability after genetic diagnosis can illuminate specific phenotypes and mechanisms relevant to common neurodevelopmental disorders. We report the neurological, cognitive and neuroanatomical characteristics of nine males from three families with loss-of-function mutations in ZDHHC9 (OMIM #300799). METHODS All known cases of ...
متن کاملMental deterioration at epilepsy onset: a hypothesis.
In this study, we hypothesized a type of mental deterioration in epilepsy, characterized as a discontinued, cascading process, i.e. a sudden mental decline in a limited time interval, immediately after the onset of the seizures. The posttraumatic epilepsy model (PTE) may appear to be exceptionally useful in avoiding one of the major methodological obstacles for testing this hypothesis, i.e. the...
متن کاملAge at onset of epilepsy, pharmacoresistance, and cognitive outcomes: a prospective cohort study.
OBJECTIVES Increasing evidence suggests that uncontrolled seizures have deleterious effects on cognition and behavior, particularly in the developing brain. METHODS In a community-based cohort, 198 children, aged <8 years with new-onset epilepsy were followed prospectively and reassessed with the Wechsler Intelligence Scales for Children, Third Edition (WISC-III) 8-9 years later. Linear regre...
متن کاملLonger duration of epilepsy and earlier age at epilepsy onset correlate with impaired cognitive development in infancy.
We assessed the impact of age at onset of epilepsy and duration and frequency of seizures on cognitive development in children less than 3 years old. Retrospective analysis was conducted on clinical data and neuropsychological testing of 33 infants with epilepsy. Developmental quotients were calculated and were correlated with age at epilepsy onset, duration of epilepsy, seizure frequency, brai...
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ژورنال
عنوان ژورنال: Pediatric Neurology Briefs
سال: 2009
ISSN: 2166-6482,1043-3155
DOI: 10.15844/pedneurbriefs-23-9-7